Clinical meaning
Acute Postinfectious Glomerulonephritis involves disruption of renal filtration, tubular function, electrolyte homeostasis, or acid-base balance specific to acute postinfectious glomerulonephritis.
Diagnosis & workup
Diagnostics & workup: - Urinalysis with microscopy (casts, crystals, cells) - PTH and vitamin D levels for renal osteodystrophy assessment - Urine albumin-to-creatinine ratio (UACR >30 mg/g = albuminuria) - Renal biopsy for unexplained proteinuria, hematuria, or AKI - Serum creatinine with eGFR calculation (CKD-EPI equation) - 24-hour urine collection for proteinuria quantification and CrCl - Complement levels (C3, C4) for glomerulonephritis workup
Risk factors: - Age >60 with age-related GFR decline - Multiple myeloma with cast nephropathy - NSAID use >7 days (prostaglandin-mediated afferent arteriolar constriction) - Rhabdomyolysis from trauma, statins, or extreme exertion - Diabetes mellitus (leading cause of CKD, 44% of new ESRD) - Recurrent UTIs or urinary tract obstruction - Sickle cell disease with papillary necrosis