Clinical meaning
Systemic and Pulmonary Circulation involves specific alterations in systemic and pulmonary circulation physiology. The pathophysiology of Systemic and Pulmonary Circulation encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of systemic and pulmonary circulation.
Diagnosis & workup
Diagnostics & workup: - Thyroid function tests (hyperthyroidism causes high-output states) - CBC with differential (anemia worsens cardiac ischemia) - 12-lead ECG: assess rhythm, intervals, ST-T changes, axis deviation - Echocardiography: EF, wall motion, valvular function, chamber dimensions - Stress testing (exercise or pharmacologic) with nuclear or echo imaging - BMP including potassium, magnesium, calcium for arrhythmia workup - Lipid panel: total cholesterol, LDL, HDL, triglycerides