Clinical meaning
Marfan Cardiac involves specific alterations in marfan cardiac physiology. The pathophysiology of Marfan Cardiac encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of marfan cardiac.
Diagnosis & workup
Diagnostics & workup: - CBC with differential (anemia worsens cardiac ischemia) - Thyroid function tests (hyperthyroidism causes high-output states) - Stress testing (exercise or pharmacologic) with nuclear or echo imaging - TEE for valvular vegetation, intracardiac thrombus, PFO assessment - 12-lead ECG: assess rhythm, intervals, ST-T changes, axis deviation - Chest X-ray: cardiac silhouette, pulmonary vascularity, effusions - Ambulatory blood pressure monitoring for white coat vs masked HTN
Risk factors: - Dyslipidemia (LDL >130 despite lifestyle modification) - Cocaine or amphetamine use causing coronary vasospasm - Atrial fibrillation or flutter with rapid ventricular rate - Peripheral artery disease (ABI <0.9) - Chronic hypertension with end-organ damage - Chronic inflammatory conditions (RA, SLE, psoriasis) - Hypercoagulable states (Factor V Leiden, antiphospholipid)