Clinical meaning
Pulmonary Hypertension involves specific alterations in pulmonary hypertension physiology. The pathophysiology of Pulmonary Hypertension encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of pulmonary hypertension.
Diagnosis & workup
Diagnostics & workup: - Troponin I or T serial measurements (0h, 3h, 6h) for myocardial injury - Holter or event monitor for intermittent arrhythmia detection - CT angiography of chest for aortic or pulmonary vascular pathology - Cardiac catheterization: coronary anatomy, hemodynamic measurements - Ankle-brachial index for peripheral vascular disease screening - TEE for valvular vegetation, intracardiac thrombus, PFO assessment - Coagulation studies: PT/INR, aPTT, D-dimer