Clinical meaning
Cerebral Venous Sinus Thrombosis involves disruption of neuronal signaling, neurotransmitter balance, or structural integrity within the central or peripheral nervous system. Cerebral Venous Sinus Thrombosis pathophysiology encompasses mechanisms including excitotoxicity, demyelination, ischemic injury, and neurodegeneration.
Diagnosis & workup
Diagnostics & workup: - Glasgow Coma Scale (GCS) for consciousness level assessment - CT angiography of head and neck (vessel occlusion, aneurysm, dissection) - Lumbar puncture with CSF analysis (cell count, protein, glucose, cultures, oligoclonal bands) - Mini-Mental State Exam (MMSE) or MoCA for cognitive screening - Carotid duplex ultrasound for extracranial stenosis - Visual field testing and fundoscopic exam for papilledema - MRA or CTA for intracranial vascular evaluation
Risk factors: - Atrial fibrillation with cardioembolic stroke risk - Family history of neurological disease (first-degree relative) - Prior head trauma or TBI history - Genetic mutations (Huntington HTT, APOE4 for Alzheimer's) - Sleep deprivation or circadian rhythm disruption - Chronic migraine with aura (increased stroke risk in women on OCPs) - Autoimmune conditions (MS, myasthenia gravis predisposition)