Wound irrigation is a critical component of wound management that directly impacts healing trajectory and infection rates. The nurse must integrate knowledge of wound healing physiology when selecting irrigation solutions, pressures, and techniques. Acute wounds progress through hemostasis, inflammation, proliferation, and remodeling phases, each requiring tailored management. Normal saline (0.9% NaCl) remains the gold standard irrigation solution as it is isotonic and non-cytotoxic to fibroblasts and keratinocytes. Antiseptic solutions (povidone-iodine, hydrogen peroxide, Dakin's solution) are cytotoxic to healing tissue and reserved for heavily contaminated or infected wounds where bacterial burden outweighs tissue damage concerns. The nurse performs comprehensive wound assessment using standardized tools, selects appropriate irrigation parameters, differentiates between wound types requiring different management approaches, and coordinates wound care planning.