Overview
Clinical Orientation
Zollinger Ellison syndrome (ZES) is the clinical syndrome produced when a gastrin secreting neuroendocrine tumor, or gastrinoma, drives excessive gastric acid secretion.
NCLEX-RN
NCLEX-RN
Zollinger-Ellison syndrome (ZES) is the clinical syndrome produced when a gastrin-secreting neuroendocrine tumor, or gastrinoma, drives excessive gastric acid secretion. Gastrinomas arise mainly in the duodenum or pancreas. Acid injury can cause recurrent or severe peptic ulcer disease, gastroesophageal reflux disease (GERD), diarrhea, and serious complications. Most ZES is sporadic. About 20% to 25% of cases occur with multiple endocrine neoplasia type 1 (MEN1), an inherited syndrome associated with parathyroid, pituitary, and pancreatic or duodenal endocrine tumors. The nursing mental model is: recognize the acid-hypersecretion pattern, protect acid control during diagnostic planning, and assess both ulcer complications and tumor-related disease.
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