Overview
Clinical Meaning
Accurate HTN diagnosis requires standardized measurement and exclusion of white coat and masked HTN.
Accurate HTN diagnosis requires standardized measurement and exclusion of white coat and masked HTN. Office BP measurement must follow the AHA protocol: patient seated 5 minutes, back supported, feet flat, arm at heart level, bladder covering ≥80% of arm circumference, no caffeine/smoking for 30 minutes prior, empty bladder. Average ≥2 readings on ≥2 occasions confirms diagnosis. Out-of-office confirmation is recommended: ambulatory BP monitoring (ABPM) is the gold standard (24-hour mean ≥125/75, daytime ≥130/80, nighttime ≥110/65 confirm HTN). Home BP monitoring (HBPM) uses an average ≥135/85. White coat HTN (elevated office, normal ABPM/HBPM) occurs in 15-30% of patients and should be monitored but not necessarily treated. Masked HTN (normal office, elevated ABPM/HBPM) carries the same risk as sustained HTN and must be treated. Secondary HTN should be suspected when: onset before age 30 or after 55, resistant HTN (3 drugs including diuretic), sudden worsening of previously controlled HTN, severe/accelerated HTN, or clinical clues suggesting secondary cause. The most common secondary causes are: primary aldosteronism (5-10% of HTN; HTN + hypokalemia + metabolic alkalosis; screen with aldosterone-to-renin ratio), renovascular HTN (renal artery...
