Pathophysiology
Clinical meaning
The cardiovascular system is essential for maintaining homeostasis by ensuring adequate blood flow to tissues. At the cellular level, cardiomyocytes (heart muscle cells) and endothelial cells (lining blood vessels) play crucial roles. Cardiomyocytes rely on aerobic metabolism for energy, and ischemia can lead to cell death and necrosis. The heart's electrical conduction system, including the sinoatrial node (SA node), regulates heart rhythm. Dysfunction in this system can lead to arrhythmias. Vascular endothelial dysfunction, often due to inflammation or oxidative stress, can result in atherosclerosis, narrowing blood vessels and increasing resistance. This pathophysiological cascade contributes to hypertension and heart failure, where the heart's output is compromised, leading to further systemic effects.