Risk stratification is the systematic process of categorizing patients into risk groups to guide clinical decision-making regarding diagnostic workup intensity, treatment aggressiveness, and follow-up frequency. The NP applies validated scoring systems that integrate multiple patient variables to generate individualized risk estimates. Key risk stratification tools include: HEART score for chest pain (History, ECG, Age, Risk factors, Troponin — low risk ≤3 allows safe early discharge), CURB-65 for pneumonia severity (Confusion, Uremia, Respiratory rate, Blood pressure, age ≥65 — score ≥2 suggests hospital admission), CHA2DS2-VASc for stroke risk in AF (score ≥2 in men or ≥3 in women warrants anticoagulation), ASCVD 10-year risk calculator for statin decisions (≥7.5% = benefit from statin therapy), Wells score for PE probability (guides D-dimer vs. CTPA decision), MELD score for liver disease severity (guides transplant listing priority), and Child-Pugh classification for cirrhosis. The clinical utility of risk stratification depends on validation in appropriate populations, appropriate calibration (predicted risk matches observed outcomes), and clinical action thresholds that are clearly defined. Risk scores should supplement, not replace, clinical judgment. The NP must recognize that no scoring system...