Scleroderma/Systemic Sclerosis involves specific alterations in scleroderma/systemic sclerosis physiology. The pathophysiology of Scleroderma/Systemic Sclerosis encompasses changes in myocardial contractility, cardiac conduction, vascular resistance, endothelial function, or structural integrity depending on the primary mechanism involved. Key cellular processes include ion channel dysfunction, inflammatory mediator activation, oxidative stress, fibrotic remodeling, and neurohormonal dysregulation that drive the clinical manifestations of scleroderma/systemic sclerosis.