The nurse managing post-angiography care independently assesses for and manages access site complications, implements evidence-based CIN prevention protocols, and coordinates transitions of care. Understanding vascular closure device (VCD) mechanisms is essential: Angio-Seal uses a bioabsorbable anchor-collagen plug sandwich to seal the arteriotomy; Perclose ProGlide uses percutaneous suture-mediated closure; MynxGrip uses a polyethylene glycol (PEG) sealant deployed extravascularly; StarClose uses a nitinol clip to approximate the arteriotomy edges. Each device has specific monitoring requirements and potential complications (device failure, arterial occlusion, infection, distal embolization of device components). The nurse also manages hemodynamic monitoring in the post-PCI period: assessing for stent thrombosis (acute recurrence of ischemic symptoms with ST changes), heart failure exacerbation (contrast-induced volume overload or periprocedural MI causing new LV dysfunction), and vasovagal reactions (common during sheath removal: sudden bradycardia, hypotension, diaphoresis, nausea -- treated with atropine, IV fluids, and leg elevation). The nurse implements standardized care bundles that reduce complications, including hydration protocols, medication reconciliation, access site assessment algorithms, and structured handoff communication.