Clinical meaning
Metabolic Respiratory Disturbances involves alterations in airway structure, gas exchange, or pulmonary vascular function. Metabolic Respiratory Disturbances pathophysiology includes changes in ventilation-perfusion matching, airway resistance, and pulmonary compliance.
Diagnosis & workup
Diagnostics & workup: - Bronchoscopy with BAL for diagnostic sampling - CT chest high-resolution for interstitial/parenchymal disease - CT pulmonary angiography for PE evaluation - Procalcitonin for bacterial vs viral pneumonia differentiation - D-dimer (high sensitivity, low specificity for PE) - 6-minute walk test for functional capacity assessment - Polysomnography for sleep-disordered breathing
Risk factors: - Environmental allergen sensitization (dust mites, mold, pollen) - Family history of alpha-1 antitrypsin deficiency - Childhood asthma with persistent airway hyperreactivity - Cystic fibrosis genotype (CFTR mutations) - GERD with chronic microaspiration - Connective tissue disease with ILD predisposition - Prior TB exposure or latent TB infection