Evidence-based practice (EBP) integrates the best available research evidence with clinical expertise and patient values/preferences to guide healthcare decisions. The EBP process follows seven steps: cultivate a spirit of inquiry, ask a clinical question using PICO(T) format, search for the best evidence, critically appraise the evidence, integrate evidence with clinical expertise and patient preferences, evaluate outcomes, and disseminate results. The PICO(T) framework structures clinical questions: Population (patient group), Intervention (treatment or exposure), Comparison (alternative intervention), Outcome (desired result), and optionally Time. Evidence is ranked by hierarchy of strength: systematic reviews and meta-analyses at the top, followed by randomized controlled trials (RCTs), cohort studies, case-control studies, case series/reports, and expert opinion at the bottom. Practical nurses contribute to EBP by identifying clinical problems, participating in evidence implementation, and evaluating outcomes. Evidence-based nursing practices include fall prevention bundles, pressure injury prevention protocols, hand hygiene programs, and pain management guidelines. EBP improves patient outcomes, reduces healthcare costs, and standardizes care quality.