Overview
Clinical Meaning
Prostate cancer is the most common non skin malignancy in men and the second leading cause of cancer death in men.
Prostate cancer is the most common non-skin malignancy in men and the second leading cause of cancer death in men. The vast majority (95%) are adenocarcinomas arising from the glandular epithelium of the peripheral zone of the prostate. Prostate cancer is hormone-dependent — testosterone (converted to dihydrotestosterone by 5-alpha-reductase within prostate cells) drives cancer cell growth. This hormonal dependency is the basis for androgen deprivation therapy (ADT), which remains a cornerstone of treatment for advanced disease. The Gleason grading system evaluates tumor architecture on biopsy (two most common patterns scored 1-5, summed for total Gleason score 2-10; higher scores indicate more poorly differentiated, aggressive tumors). Localized prostate cancer may be managed with active surveillance (for low-grade, low-volume tumors), radical prostatectomy, or radiation therapy. The nurse monitors PSA levels (prostate-specific antigen — used for screening and monitoring treatment response, though it is organ-specific, not cancer-specific), assists with post-prostatectomy care (catheter management, pelvic floor exercises), monitors for treatment side effects (urinary incontinence, erectile dysfunction from surgery; bowel/bladder irritation from radiation; hot flashes, osteoporosis, metabolic effects from ADT), and provides psychosocial support for...
