Overview
What the ANC Tells You
Neutropenia is an absolute neutrophil count (ANC) below 1.5 × 10⁹ cells/L.
REx-PN
REx-PN
Neutropenia is an absolute neutrophil count (ANC) below 1.5 × 10⁹ cells/L. Severe neutropenia is an ANC below 0.5 × 10⁹ cells/L. The ANC, rather than the total white blood cell count, tells you how much immediate neutrophil-mediated infection defence remains. Neutrophils are among the first immune cells recruited to bacterial and fungal threats. When their numbers are very low, infection may advance with little pus, redness, or local swelling. A patient can therefore appear relatively well while developing a life-threatening infection. The absence of dramatic inflammation is not reassurance; it may be a consequence of the neutropenia. Neutropenic precautions reduce exposure to organisms while the patient is vulnerable. They do not treat the neutropenia and they never replace prompt assessment of fever or deterioration. The risk is highest when the ANC is below 0.5 × 10⁹ cells/L, particularly after myelosuppressive chemotherapy.
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